Isaac married Wise, Susannah in 1638 in Ipswich, Essex, Massachusetts. Susannah (daughter of Wise, Humphrey and Tidd, Susanna) was born in INT 1618 (ABT 1618/1678) in Ipswich, Essex, Massaschusetts; was christened in in Of Ipswich, Essex, Massachusetts; died on 17 Jul 1699 in Newcastle, Newcastle, de. [Group Sheet] [Family Chart]